The R2D2-MH approach

Interdisciplinarity is essential to translational research and bridging academic research into the real world. It promotes disruptive innovation through combined interdisciplinary perspectives and expertise and has proven impact. R2D2-MH will apply a highly interdisciplinary approach integrating diverse expertises in constent interaction with citizens and stakeholders.

R2D2-MH Approach

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R2D2-MH relies on 6 research outcomes that will be conducted in regular communication with the society and stakeholders:

1 – Identify Risk and Resilience (R2) factors
2 – Characterize brain signatures of Developmental Diversities (D2)
3 – Contribute to new mental health (MH) measures
4 – Develop digital tools for clinical management and positive psychology
5 – Develop predictive models for optimisation of clinical management
6 – Disseminate, communicate, and exploit to the public, health authorities and policy makers

Objectives of the R2D2-MH project

The overall goal of R2D2-MH is to improve mental health outcomes across the lifespan for young individuals with mental health or neurodevelopmental diversities.

The R2D2-MH project will focus on the following 7 objectives:

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Provide the largest European multi-scale dataset on early brain and mental health diversity in humans


Identify biological mechanisms of resilience associated with diverse mental health outcomes in neurodevelopmental diversities


Provide new in vitro models as human brain organoids to study neurobiological models of risk and resilience


Increase participatory research/medicine and reduce Mental Health stigma


Develop a positive psychology e-Health App to improve the well-being of children with NDDs and their parents


Develop an open platform for healthcare providers to record real-life data and to improve healthcare management


Co-develop a first generation of predictive models of risk and resilience for poor mental health outcomes

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Target groups, outcomes and impacts of the project

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Citizens & Families

are involved in the research strategy and empowered to self-manage their health, overall contributing to tailored outcomes and reduction of stigma surrouding NDDs

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benefit from newly established in vitro and in silico models as well as approachs that can be further used in other research initiatives

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Healthcare givers

benefit from new clinical guidance and improved prediction of response to real-world intervention

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Policy makers

have access to the voice of end-users and key stakeholders (co-creation) and benefit from the production of core sets and white papers outlining how research outcomes will be incorporated in future policies

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Industry partners

benefit from new models and research outcomes that will pave the way towards new interventions in the field of neurodevelopmental disorders and mental health